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Alectinib synthetic routes

Brivaracetam - Synthetic Route

CAT#: 326678 | Name: Brivaracetam | CAS#

Purchases for research

Description:

Brivaracetam, also known as UCB 34714, is a chemical analog of levetiracetam, is a racetam derivative with anticonvulsant (antiepileptic) properties approved for the treatment of epilepsy. Brivaracetam was discontinued.

Synthetic Routes

Brivaracetam - Synthetic Route 1

Brivaracetam - Synthetic Route 1

Synthetic reference

Ciceri, Samuele; Grisenti, Paride; Elahi, Shahrzad Reza; Ferraboschi, Patrizia. A new chemoenzymatic synthesis of the chiral key intermediate of the antiepileptic brivaracetam. Molecules.Volume 23. Issue 9.Pages 2206/1-2206/11. 2018.

Brivaracetam - Synthetic Route 2

Brivaracetam - Synthetic Route 2

Synthetic reference

Huang, Shaozhi; Shi, Lei; Chen, Yiwen; Xu, Yawen. Method for preparing brivaracetam. CN 105646319. (Assignee Foshan Longxin Pharmaceutical Science and Technology Co., Ltd., Peop. Rep. China)

Brivaracetam - Synthetic Route 3

Brivaracetam - Synthetic Route 3

Synthetic reference

Wang, Chunyan; Chen, Zhiyong; Wang, Cong. Preparation method of brivaracetam and its intermediate. CN 106748950. (Assignee Chengdu Miracle Pharmaceutical Co., Ltd., Peop. Rep. China)

Brivaracetam - Synthetic Route 4

Brivaracetam - Synthetic Route 4

Synthetic reference

Liu, Xingxin; Wu, Liming; Li, Qian; Xiao, Jianyang; Guo, Peng. Synthesis method of brivaracetam from pentanoic acid or pentoyl halide. CN 107216276. (Assignee AstaTech (Chengdu) Biopharmaceutical Co., Ltd., Peop. Rep. China)

Brivaracetam - Synthetic Route 5

Brivaracetam - Synthetic Route 5

Synthetic reference

Kenda BM, Matagne AC, Talaga PE, Pasau PM, Differding E, Lallemand BI, Frycia AM, Moureau FG, Klitgaard HV, Gillard MR, Fuks B, Michel P. Discovery of 4-substituted pyrrolidone butanamides as new agents with significant antiepileptic activity. J Med Chem. 2004 Jan 29;47(3):530-49. PubMed PMID: 14736235.

Brivaracetam - Synthetic Route 6

Brivaracetam - Synthetic Route 6

Synthetic reference

Ates, Celal; Lurquin, Francoise; Quesnel, Yannick; Schule, Arnaud. Preparation of 4-substituted-pyrrolidin-2-ones and their uses for the synthesis of 2-oxo-pyrrolidin-1-yl derivatives. WO 2007031263. (Assignee UCB S. A., Belg.)

Brivaracetam - Synthetic Route 7

Brivaracetam - Synthetic Route 7

Synthetic reference

Schule, Arnaud; Merschaert, Alain; Szczepaniak, Christophe; Marechal, Christophe; Carly, Nicolas; O'Rourke, John; Ates, Celal. A Biocatalytic Route to the Novel Antiepileptic Drug Brivaracetam. Organic Process Research & Development. (UCB Pharma S.A.)

Brivaracetam - Synthetic Route 8

Brivaracetam - Synthetic Route 8

Synthetic reference

Ates, Celal; Schule, Arnaud. Preparation of 1-carbamoylalkyl-3-carboxy-2-oxopyrrolidines. WO 2007065634. (Assignee UCB Pharma, S. A., Belg.)

Brivaracetam - Synthetic Route 9

Brivaracetam - Synthetic Route 9

Synthetic reference

Wang, Peng; Li, Pixu; Wei, Qiang; Liu, Yuanhua. Processes to produce brivaracetam. WO 2016191435.

Brivaracetam - Synthetic Route 10

Brivaracetam - Synthetic Route 10

Synthetic reference

Defrance, Thierry; Septavaux, Jean; Nuel, Didier. Process for preparing brivaracetam. WO 2017076738. (Assignee UCB Biopharma Sprl, Belg.)

Brivaracetam - Synthetic Route 11

Brivaracetam - Synthetic Route 11

Synthetic reference

Kumar, Pramod; Sankareswaran, Srimurugan; Mannam, Madhavarao; Gaddam, Venugopal Reddy; Chiluukuru, Srikanth; Chaubey, Bipin Kumar. Novel process for the preparation of Brivaracetam. WO 2018042393. (Assignee Micro Labs Limited, India)

Brivaracetam - Synthetic Route 12

Brivaracetam - Synthetic Route 12

Synthetic reference

Ciceri, Samuele; Grisenti, Paride; Elahi, Shahrzad Reza; Ferraboschi, Patrizia. A new chemoenzymatic synthesis of the chiral key intermediate of the antiepileptic brivaracetam. Molecules.Volume 23. Issue 9.Pages 2206/1-2206/11. 2018.